The brothers Mokong and Bubuli (sons of Lucring Dayukdok) have feelings for the rich sisters Honey Grace and Barbie Doll (daughters of Don Robert Dinero), Mokong for Honey Grace and Bubuli for Barbie Doll. Don Robert doesn’t like the brothers because they are poor. So that they can be free to court Honey Grace and Barbie Doll, Mokong and Bubuli climb over the fence.
Famous plastic surgeon Dr. Hugo (Christopher de Leon) has a fiancée Alicia (Nanette Medved) and feels that her face is his greatest creation. Originally a monstrous carnival attraction, she was transformed into a beautiful and glamorous woman through surgery. Alicia learns that beauty is not everything that she imagined it to be. She finds it difficult to discern whether people like her for her personality, or only because she is rich and beautiful. She yearns for her former self, the ugly Carissa. As Carissa, she felt sure that those who liked her were not attracted by her appearance. One such person was her former neighbor and lover, Mendez (Cesar Montano).
The story focuses on the three brothers Andrew E., Jimmy Santos, and Keempee de Leon. They live in the slums of Manila as "bakal-dyaryo-bote" collectors recycling scrap metal, newspapers and empty beverage bottles. Later on, They discover that Jimmy Santos, the ugliest of the three brothers, is the only heir of a rich yet an ugly tycoon in Manila (played by Zorayda Sanchez)who was lucky enough to marry a wealthy man played by Eddie Gutierrez.
Famous singer, Monique (Sharon Cuenta) escapes her home after her mother is in disbelief that her stepfather tried to assault her. She goes into hiding by altering her looks and assumes the name, Digna. She goes living in a shelter for women and works various odd jobs. With her past coming back to haunt her again, Monique's fate is altered with a chance encounter with Carding (Robin Padilla), a small, petty thief who looks after six orphaned children.
A teenage boy befriends a well known B class actress Rachelle (Dina Bonnevie) who is having an affair with a Mayor Edmundo Guatlo (Eddie Garcia) whose wife Rowena (Charo Santos-Concio) wants to get rid of her in order to not snag controversy during the elections but in only two clauses she will disappear if he releases her lover out of prison (Christopher De Leon) and kill his rival opponent in the elections. Brocka's Gumapang Ka sa Lusak shows the evils of society, corruption and epidenious world of glitz, and disaster in the world of the ruling influential, society of politics and the message of life trying to make a living from the dirt and gravel of society we all struggle to live in.
On the outside, married couple Fina (Santos) and Rodel (Manzano) Alcaraz appear to be a match made in heaven, but behind the thick walls of their home, their relationship is on the verge of crumbling. Despite being relatively affluent, the couple is empty as they are childless, for any attempt to conceive might prove fatal to Fina due to her condition. In an act of desperation, Rodel takes matters into his own hands and seeks the services of a surrogate, Ditas (Bonnevie).
Soriano brothers Dennis, Chipipoy/Chip, and Jeff are bums who do odd jobs to earn a living, including driving a jeepney. Their lives take a different turn after meeting Atty. Aga Agaton, who told them that they are long-lost heirs of a US-based millionaire. Per the millionaire's will, the brothers would claim his inheritance as long as they finish high school or else the lawyer will take it all.
With director Gil Tejada Jr. at the helm, Gaano Kadalas ang Minsan is about the intertwined love and lives of Louie (Marvin Agustin), Lily (Camille Pratts) and Elsa (Diana Zubiri). Elsa and Lily are best friends despite their social differences. Elsa's family owns the hospital where Lily and her boyfriend Louie work as a nurse and as a doctor respectively. Unknown to Lily, Elsa is secretly in love with Louie and will even plan a scheme to send the nurse away.