The film focusses on a family living in Hyderabad whose head is Ram Murthy (Nagineedu), a retired head master. He is a disciplined person and always tries to make his relatives behave in the same way. To avoid bad remarks from the society about his family, he sets up a family constitution of discipline. His mania for discipline is such big that if any one of his family members commit 100 Mistakes, that person would be banished from the family and that mistake can be anything which Ram Murthy hates which ironically includes laughing out loudly. Thus all of the family members maintain a disciplinary life to avoid being banished from the house. In detail, the family consists of Ram Murthy's wife Seetha, an Asthma patient; his daughter Kasthuri, his son in law Anand and their kids. Apart from them are Ram Murthy's two sons Brahmaji (Brahmaji) and Sundeep (Sundeep Kishan). Since Ram Murthy's brother Subrahmanyam (Prithviraj) was alleged to be committed 100 Mistakes though he didn't, he is sent away from home. While all of the family members commit mistakes less than 20, Sundeep commits 99 Mistakes and one more, he is out of the family. So to avoid that Sundeep starts leading a careful life. Brahmaji's marriage is scheduled at Tirupathi and the whole family boards Venkatadri Express at Kacheguda. Sundeep's mother forgot the Mangala sutra at the house and Sundeep goes away to bring it back. Moreover to his convenience, Sundeep is in S4 while others are in S3. So Sundeep goes outside the station and waits for an Auto-Rickshaw, But none accepts to go to his area. Meanwhile a miser techie Prarthana (Rakul Preet Singh) reaches Kachiguda railway station to board the Venkatadri Express and the Auto-Rickshaw driver goes to bring the change in order to pay her off the balance amount after receiving the fare. Sundeep gets into the vehicle and goes to his home. He breaks the house's lock with a stone as he has no keys to open it. He takes the Mangala sutra and goes back to Kacheguda Railway Station. Prarthana catches yet another auto and reaches to the station. There she pays off the fares of both the vehicles and goes to board the train.
Varun (Varun Sandesh), the son of a middle-class man (Tanikella Bharani), is fit for nothing in the beginning. Though he wants to do something with his life, he knows he cannot get a job, just as he could not get a costly education, as his father is not someone who can bribe Rich men for a job to his son. On the night of his birthday, he spills out his frustration to his father who beats him for consuming liquor. Life changes for the good the next morning, when Varun's father gives away the sum he has saved for the daughter's wedding to Varun. The lad, who has been dreaming of owning a bike, gets one and whizzes off in life. A lucky talisman for him, he develops an emotional attachment to it as he sees it as the reason for his upward mobility. After it entered his life, he has got everything he had desired - father's affection, a job and Hema's (Neha Sharma) love for which he has been thirsting for two years now.
Swapna (Aarthi Chabria) is a NRI who has come to India for a visit along with her grandfather. Kameshwar rao (Srikanth) is on a pilgrimage to Kaasi on the request of his grandmother as he had completed graduation successfully. Kamesh sees Swapna at a railway station and falls in love with her at the first sight.
Ravi, played by Uday Kiran, is the son of a multimillionaire in Hyderabad. Vasundhara (Anita), is the daughter of a milk supplier. Ravi and Vasundhara both study in same college. The film starts with Vasundhara showing hatred towards Ravi, as he is a sportsman who is not good in his studies. Over a period of time, her hatred turns into love. Finally, they both fall in love, but their parents do not agree for their marriage. Parents plan to avoid the marriage by giving the couple a clause that they should not meet each other for one year. If their love remains even after one year then their parents would agree to let them marry.