Karthik (Naga Chaitanya) is a mechanical engineering graduate but aspires to become a filmmaker. Through his friend, Karthik gets introduced to director Puri Jagannadh. With his support,Karthik family, who are Hindus, rents the ground floor of a two-storeyed house which belongs to the Thekekuttus. The Thekekuttu family is a conservative Malayali Syrian Catholic family from Alappuzha, Kerala, who live upstairs. The Thekekuttus have a daughter, Jessie (Samantha), who is 2 years older to Karthik. When Karthik meets Jessie for the first time, he falls in love with her. Karthik expresses his love one day to her, who is afraid of speaking to men around her strict father, and ends up angering Jessie. The two meet several times afterwards and Jessie begins to admit that she likes Karthik but wants to refrain from any problems because she knows her father won't accept a Hindu marrying their daughter. Her parents learn about their affair and arrange a marriage for her. But at the wedding, she refuses to marry the groom, displeasing everyone in her family. Karthik and Jessie continue to love each other without the knowledge of their parents. Suddenly, Jessie is forced by her father to marry and seeks Karthik's help, who was in Goa for a film shooting. Busy Karthik is unable to attend to her calls and messages; Jessie is unable to reach him. After a tense phone call from Jessie, Karthik goes back one night to check on her. An angry and hurt Jessie makes a final decision to break up with Karthik because of her father's strong disapproval of their love.
Raj (Indrajeet) and Pooja (Manjula Swaroop) are a married couple who move into a new house with their children. Desperate for a nanny to take care of their children, they hire Kavya who is unemployed, after she saves Pooja's life. Kavya grows close to the family and they come to consider her part of the family. However, as the movie progresses, it is revealed that Kavya was the wife of a gynecologist who committed suicide after Pooja accused him of sexually assaulting her. Other patients supported this claim and he eventually committed suicide. In an attempt to save him, Kavya accidentally miscarries. She eventually tries to destroy the family and kill Pooja to get revenge for her loss. The movie is a remake of the English movie, 'The Hand that Rocks the Cradle'.
In Hyderabad, two rival mafia gangs headed by Dubai-based don Ali Bhai, and Narayana resort to criminal activities such as extortion, murder, and coercion for various reasons. The new commissioner of police, Sayyad Mohammad Pasha Qadri, focuses on making the city a better place by working at arresting all of them. Pandu, a remorseless gangster living in Hyderabad along with his friends, is hired by Narayana and attacks Ali Bhai's henchmen. He later joins Ali Bhai's gang for monetary reasons. He falls in love with Shruti, an aerobics teacher, who rejects his advances.
Naani an eight-year-old boy who is very mischievous always troubling his mother. His mother scolds him when he eats the toothpaste, urinate in bed at night. Naani falls down on a road one day and a young woman helps him. Naani's elder brother plans to watch adults movie with his friends in the absence of their parents and Naani demands him to join him to which his brother does not allow him. Angered, Naani cuts off the power which creates a short circuit at home. Naani's mother scolds for his dangerous mischief and shouts at her husband for not stopping with one child as Naani is troubling her a lot. This hurts Naani and he runs away from home to jump into a river. But he is stopped by an old man and he takes Naani to his place. The old man introduces himself as a scientist who has his own laboratory. He insists Naani to help him in his research of transforming a child to a young man. Naani agrees and the scientist transforms him to a young man. Naani starts to live as a young man physically but as a child mentally and stays away from his family. The only person other than scientist who knows the truth is his child classmate friend. Naani meets the girl at a park who helped him once he fell down on road. Innocent child Naani helps to remove dust from her eyes, smiles at her and leaves the place. The girl is very much attracted towards him and she looks for him every day.
Ridhima (Manjula), an executive from Delhi-based pharmaceutical company visits a remote village in AP to make a deal on patents with a professor who invented a new drug. The professor leaves a note that he would return late as he had to attend some urgent work and she shall wait for his arrival. At that time Madhav Rao, a junior lawyer who supervises the event of patent selling arrives at that place. Ridhima is a fun loving unmarried girl. Madhav Rao is a frustrated married guy. The events that take place for a few hours between these two makes up the story.